Serological Confirmation of Human Herpesvirus Type 6 Infection in Different Age Groups

HHV – 6 has been identified as the etiologic agent of exanthem subitum (roseola infantum) in childen (6 -24 months) with primary infection. 354 sera at various age groups were tested and 161 sera from children in more detail. Since that date, 4 such cases have been reported from the US and Europe. Your library or institution may give you access to the complete full text for this document in ProQuest. By PCR we detected human papilloma viruses (HPV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), and for the first time human herpesvirus 7 (HHV-7) in the KS. The results show that DNA replication of HHV-6 produces head-to-tail concatemeric intermediates as well as approximately equal amounts of circular monomers or oligomers. Herpesviruses infections are common sexually transmitted diseases in homosexual men, who are also the main risk group for developing Kaposi’s sarcoma.

The virus was later shown to have a marked tropism for CD41 T-cells and was renamed HHV-6. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. Examination of consecutive serum samples from patients with illnesses compatible with acute cytomegalovirus infection or exanthem subitum by indirect immunofluorescence for the presence of antibodies to human herpesvirus type 6. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. Recent studies have indicated that HHV-6 DNA is detected with high frequency in MS lesions compared to normal-appearing white matter, implicating a role for HHV-6 in MS pathogenesis. In order to investigate herpesvirus (HHV) role in the susceptibility to skin cancer, we compared HHV6 and HHV1 incidence in DNA samples extracted from 120 lesions and 41 normal skin tissues. Around 5.2 million people in the UK are estimated to have asthma.


Department of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan. Isolation of HHV-6 from peripheral blood mononuclear cells concomitant with a rise in antibody against HHV-6 was reported in 10% to 15% of children younger than 2 years presenting with fever to a pediatric emergency center. Recently, CD46 has been identified as the cellular receptor for human herpesvirus Type 6 (HHV-6). Objectives. Could another doctor or a PA at your same doctor’s office see you sooner? Thus, these data support the conclusion that latency is immunologically silent. Intrathecal immunoglobulin (Ig) production with oligoclonal CSF bands are hallmarks of both MS and infections of the CNS.

It further relates to antibodies specifically reacting with the protein or parts thereof and to DNA sequences encoding said protein or parts thereof, to recombinant vectors containing these DNA sequences and to host organisms transformed with these vectors. Examination of consecutive serum samples from patients with illnesses compatible with acute cytomegalovirus infection or exanthem subitum by indirect immunofluorescence for the presence of antibodies to human herpesvirus type 6. The potential role of an infectious agent in MS aetiology stems from evidence of a geographical risk component, with disease being more prevalent in temperate regions. Herpesviruses infections are common sexually transmitted diseases in homosexual men, who are also the main risk group for developing Kaposi’s sarcoma. On occasion, these viruses come out of latency and initiate their replicative cycles, yielding a progeny of infectious virions favoring viral propagation and dissemination with possible pathogenic outcomes depending on the immunological competency of the host. In order to evaluate the prevalence of HHV-6 in blood donors, we examined 112 persons by polymerase chain reaction (PCR) and ELISA. Metabolic diseases were ruled out and ultrasound found no alterations.

It has been suggested that HHV6 may be associated with severe clinical manifestations, but little is known about its exact role in patients’ outcomes following allo-CST. We have shown previously in peripheral blood mononuclear cells (PBMCs) of three patients, two with a history of lymphoma and one with multiple sclerosis, a specific target site for latent integration of the full-length HHV-6 viral genome on the distal short arm of chromosome 17, in band p13.3. We welcome you to answer the questions below and/or contact us via links below. It further relates to antibodies specifically reacting with the protein or parts thereof and to DNA sequences encoding said protein or parts thereof, to recombinant vectors containing these DNA sequences and to host organisms transformed with these vectors. Different viruses have tentatively been involved as causative agents of MS that would trigger an autoimmune response leading to demyelination plaques. HHV6 plasma loads were monitored weekly by quantitative PCR. Intrathecal immunoglobulin (Ig) production with oligoclonal CSF bands are hallmarks of both MS and infections of the CNS.

Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. After 250 passages (4 years) in protein-free medium, the cells, designated JJHan-PF, were cocultured with JJHan cells chronically infected with strain AJ of HHV-6 conventionally grown in serum-supplemented medium. Abstract OBJECTIVE: To study the relationship between human herpesvirus-6 (HHV-6) and lymphoma in China. The frequency of high (greater than 256) IgG anti-human herpesvirus type 6 (HHV-6) titers in sera known to be positive for IgM anti-cytomegalovirus (CMV) or IgM anti-Epstein Barr virus (EBV) was significantly greater than in sera from healthy controls or from a group of ill patients who were CMV and EBV IgM-negative (15/25 and 17/25 vs.