An alternative hypothesis is presented: that the encephalitis is due to a special affinity of the herpes simplex Type 1 virus for the limbic cortices, that is, that distinctive neuroanatomical, neurochemical and neuroimmunological properties of those cortices permit the virus to manifest its destructive behaviour, regardless of the route of entry to the CNS, possibly during altered immunological states. In the four cases, fever and consciousness disturbance were commonly found and convulsive seizures appeared in three. Since the introduction of “limbic encephalitis” (LE) in 1968, LE was thought to almost always be associated with carcinoma; this belief led to the coining of the term “paraneoplastic limbic encephalitis” (PLE). Bottom Line: Reactivation of human herpesvirus 6 (HHV-6) occurs frequently in patients after allogeneic stem cell transplantation and is associated with bone-marrow suppression, enteritis, pneumonitis, pericarditis and also encephalitis.This case demonstrates a severe symptomatic HHV-6 infection with encephalitis and pneumonitis after autologous stem cell transplantation of a patient with relapsed Hodgkin’s disease.Careful diagnostic work up in patients with severe complications after autologous stem cell transplantation is mandatory to identify uncommon infections. The patient had high fever, convulsion and memory disturbance soon after having caught a common cold, and was admitted to a hospital where she developed progressive disturbance of consciousness. Neuropathological changes of NHALE have been described in only one report. On admission MRI shows bilateral symmetrical involvement of medial temporal lobes, restricted diffusion with faint high signal on FLAIR, no marked focal parenchymal swelling.
You will be able to get a quick price and instant permission to reuse the content in many different ways. Neuropathological changes of NHALE have been described in only one report. Anatomical examination of the brain demonstrated massive bilateral destruction of the limbic system. Investigations revealed limbic encephalitis. In the four cases, fever and consciousness disturbance were commonly found and convulsive seizures appeared in three. The patient, Roger, has been studied in our laboratory for over 14 years, and the current article presents his complete neuroanatomical and neuropsychological profiles. The brain damage occurred in 1980 following an episode of herpes simplex encephalitis.
The diseases involving the limbic system are divided into three groups; (1) diseases in which the limbic system is more or less selectively involved, such as limbic encephalitis, herpes simplex encephalitis, cerebral confusions by the falx and tentorium, and internal herniations through the falx and tentorium; (2) diseases in which the limbic system is predominantly involved, such as arhinencephalia, holoprosencephaly, cyst of cavum septi pellucidi, Pick’s disease, Alzheimer’s disease, hippocampal sclerosis, and vascular diseases of the hippocampal formation; and (3) diseases in which the limbic system is randomly involved, such as various types of neoplasms and vascular and inflammatory lesions. Petrous bone defect was filled in with aluminium-containing bone cement (Ionocem). We describe the clinical spectrum, underlying etiology and long-term follow-up of patients with LE from India. Patient with history of peripheral paresis of right facial nerve, 1 month after symptoms appearance and treatment, developed fever, vomiting, grand mal seizure, decreased level of consciousness, confusion, hallucinations and agitation. Author manuscript; available in PMC 2013 Feb 1. On imaging, autoimmune limbic encephalitis generally affects the amygdala and hippocampus, while infectious limbic encephalitis typically involves multiple sites. IgG viral antibodies for herpes simplex virus -1, varicella zoster virus, cytomegalovirus, measles and mumps were studied in 76 subjects with obsessive compulsive disorder and compared with a control population.
Amnesia – typically refers to loss of declarative memory which is related to bilateral medial temporal lobe or bilateral medial diencephalic lesions. We had an opportunity to address this intriguing question in Patient B., who has extensive bilateral damage to most of the limbic system, including the medial and lateral temporal lobes, orbital frontal cortex, insular cortex, anterior cingulate cortex, and basal forebrain, caused by herpes simplex encephalitis. The patient was admitted to a hospital with high fever, severe liver dysfunction, and thrombocytopenia. The brain damage occurred in 1980 following an episode of herpes simplex encephalitis. The brain damage occurred in 1980 following an episode of herpes simplex encephalitis. As widespread structures as the telencephalon, diencephalon and brainstem are added to the limbic system, the traditional notion of its association with emotional experience and expression alone is being challenged. The patient was admitted to a hospital with high fever, severe liver dysfunction, and thrombocytopenia.
In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. We examined three rare autopsied cases consisting of probable one NHALE and two AJFNHLE. Two pathways for viral entry to the central nervous system (CNS) in HSE have been suggested: either via the trigeminal nerve or via the olfactory tract. 2009 Oct 20; 106(42): 17916–17920. Methods We examined three rare autopsied cases consisting of probable one NHALE and two AJFNHLE. The patient had high fever, convulsion and memory disturbance soon after having caught a common cold, and was admitted to a hospital where she developed progressive disturbance of consciousness.