Human Herpesvirus-6 in Central Nervous System Diseases

Most people are exposed to HHV-6 early in life and carry a latent form of the virus in their body. Ignorance about HHV-6 may turn the smallpox vaccination program into a major public health disaster. Montoya posted an impressive list of 30 researchers he’s collaborating with at Stanford and elsewhere. The DNA found in the serum and whole blood of a person with ciHHV-6 does not indicate active infection as it would in a person without this form of HHV-6. I remember when I started going out with one girl (this was 20 years ago). HHV-6 RNA from PBMC were amplified by RT(retrotranscription)-PCR. At the same time, as discussed later, HHV-6 has in vitro tropism for various cells of the CNS.

A year ago at the IACFS/ME Conference she stated they were “scrubbing” the data. Higher frequency of IgM antibody was also detected in CFS patients (57.1%) compared to HD (16%). Most people are exposed to HHV-6 early in life and carry a latent form of the virus in their body. Additionally, HHV-6 viral protein expression has been observed in pathological specimens [Challoner et al., 1995; Opsahl and Kennedy, 2005] but not in healthy tissues, suggesting that active viral replication may in part contribute to manifestation of clinical symptoms. Unfortunately the lack of a standard primer for HHV-6 makes comparing results across studies more difficult (Opsahl and Kennedy 2005). Human herpesvirus 6 (HHV-6) is a ubiquitous infectious agent isolated for the first time in 1986 from patients with lymphoproliferative disorders (39). Other tests show decreased cerebral blood flow.


As with so many complex chronic illnesses, CFS may be aggravated by a wide variety of environmental and physiological challenges. Data in favor of and against the correlation are discussed. Anxiety, panic attacks, and depression are common comorbidities in ME/CFS. In one study, 27 CFS patients were treated with valacyclovir four times daily or placebo. Montoya posted an impressive list of 30 researchers he’s collaborating with at Stanford and elsewhere. pneumoniae or HHV-6 was similar in mycoplasma-positive and -negative patients, suggesting that such infections occur independently in CFS patients. Along with the leading clinician Dr Peterson and the eminent scientist Prof.

HHV-6 makes a chemical that may contribute to the “brain fog” seen in CFS. Although these illnesses may present with a primary symptom other than fatigue, chronic fatigue is commonly associated with all of them. However, no statistically significant differences in antibody levels or frequency of HHV-6A or HHV-6B infection were detected between the controls and CFS patients. Given the ubiquitous nature of this virus and the challenging precedent of correlating antiviral antibodies with disease association10, these antibody studies have been supported by the detection of HHV-6 DNA from samples of MS serum as a marker of active viral infection. How can HHV-6, a common virus that purportedly goes to sleep harmlessly in the body after initial infection in almost everyone, awaken to trigger or contribute to serious illness or even death? Chronic Fatigue Syndrome and Autism (and many other so-called HHV-6 related mysterious epidemics) are part of the so-called AIDS epidemic. Caroline Hall’s group at University of Rochester studied HHV-6 in the cord blood of over 5,000 infants and only found HHV-6 DNA in infants with ciHHV-6, or in children whose mothers had ciHHV-6 (Hall 2010).

The longitudinal sampling of a healthy male over a period of 2.5 years revealed that 80% of viral contigs, which are contiguous reads of sequenced DNA, persisted over that period. Because no direct tests aid in the diagnosis of CFS, the diagnosis is one of exclusion but that meets certain clinical criteria, which are further supported by certain nonspecific tests. Few studies address this question. ^ a b “HHV-6 Foundation Board of Directors”. · Conclusions: Neurologic symptoms, MRI findings, and lymphocyte phenotyping studies suggest that the patients may have been experiencing a chronic, immunologically mediated inflammatory process of the central nervous system. Transcript levels and viral copy number were compared to patient CFS symptom severity. Some patients may fully recover between six months and a year, whereas it may take longer for others.

HHV-6A was found only in uterine endothelial cells, and not in the blood. Patients were recruited for the study by answering a standard questionnaire and by matching the Holmes’ criteria for CFS. Though often referred to as a co-infection, HHV6 is not transmitted with the Lyme infection. Fifteen human herpesvirus-6 (HHV-6) isolates from normal donors and patients with AIDS, systemic lupus erythematosis, chronic fatigue syndrome, collagen-vascular disease, leukopenia, bone marrow transplants, Exanthem subitum (roseola), and atypical polyclonal lymphoproliferation were studied for their tropism to fresh human cord blood mononuclear cells, growth in continuous T cell lines, reactivity to monoclonal antibodies, and by restriction enzyme banding patterns. Chronic fatigue syndrome/ Myalgic encephalomyelitis (CFS/ME) is a poorly understood seriously debilitating disorder in which disabling fatigue is an universal symptom in combination with a variety of variable symptoms.