High frequency of histocompatibility antigens HLA-DR3 and DR4 in herpes gestations. – PubMed

We report a series of 22 cases of PG in Kuwait. We have studied 23 patients with a history of HG, 20 of whom had typical immunofluorescence findings during the active phase of their disease. We report a series of 22 cases of PG in Kuwait. We have studied 23 patients with a history of HG, 20 of whom had typical immunofluorescence findings during the active phase of their disease. Circulating antibodies of IgG1 class are also present. In five patients the development of herpes gestationis coincided with a change in sexual partner, suggesting that the development of herpes gestationis may depend on exposure to an antigen derived from the father. Autoimmune bullous disorders are a group of severe skin diseases characterized clinically by blisters and erosions of skin and/or mucous membranes.

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease seen primarily in elderly persons. Antibodies against the extracellular domain of bullous pemphigoid antigen 2 (BPAG2) are thought to play a key role in the pathogenesis of bullous pemphigoid (BP), the most frequent autoimmune bullous disease of the skin. A previous series has demonstrated an association of PG with human leukocyte antigen (HLA)-DR3 or HLA-DR4 haplotypes. You can find out more about our use of cookies in About Cookies, including instructions on how to turn off cookies if you wish to do so. After a mean of 80 months since the onset of disease, when evaluated serologically, they had antibodies typical of PV and pemphigoid (Pg). Correlations were sought between HLA antigens and the various BP disease parameters investigated. A strong association with HLA alleles was found in pemphigus, mucous membrane pemphigoid, pemphigoid gestationis and epidermolysis bullosa acquisita, whereas in bullous pemphigoid, this association appeared much less prominent.

She was evaluated in England, assigned the diagnosis of unexplained infertility (laparoscopy and endometrial biopsy in 1996 were normal) and subsequently underwent three IVF cycles (2/9, 5/97, 10/97) that did not result in pregnancy. Method of study:  Eotaxin and interleukin (IL)-5 were analysed in patients’ blister fluid and serum by enzyme-linked immunosorbent assay. LPP is usually considered to be the coexistence of lichen planus with BP. Only one polymerase chain amplification reaction is needed and the application of a limited number of short oligonucleotide probes allows an almost complete definition of DRB alleles. Other investigations relevant to the case, treatment or as indicated during the course. It was shown that the major noncollagenous stretch of the BP180 ectodomain (NC16A) harbors epitopes recognized by HG sera. At least 43 alleles of the DRB loci and 13 alleles of the DQB1 locus are currently recognized.

The keratinocytes of epidermis are arranged in four layers, the basal cell layer, the squamous cell layer, the granular layer, and the horny layer. Autoantibodies against Dsg3 and Dsg1 are critical in the pathogenesis of PV since their transfer into newborn mice induces a phenotype resembling PV (11, 12). The prevalence rate of primary autoimmune hypothyroidism (PAIH) is 5%, and up to 8.3% if subclinical hypothyroidism is included.1 Skin manifestations associated with PAIH include a number of skin diseases common to patients with this condition (defined as the presence of autoantibodies even in a euthyroid state) and others directly dependent on thyroid function. Author manuscript; available in PMC 2010 Mar 28. Capillary walls in the kidney showed specific staining both in glomeruli and around tubuli. Although some authors consider IH as a distinct pregnancy dermatosis (3), most concur that it is a variant of generalized pustular psoriasis triggered by pregnancy. To establish an active stable BP animal model that demonstrates the persistent inflammatory skin lesions initiated by the anti-human COL17 Abs, we used COL17-humanized (COL17m−/−,h+) mice that we recently produced.

This study of 19 patients from Oxford, UK and 39 patients from New Delhi, India demonstrates that the incidence of the disease subtypes is different in the two countries, In the UK the commonest subtypes are pemphigus vulgaris and foliaceus with equal prevalence (both eight of 19), but in India pemphigus vulgaris is the must frequent (31 of 39), while pemphigus foliaceus is uncommon (three of 39) and with equal prevalence to the other subtypes. In five patients the development of herpes gestationis coincided with a change in sexual partner, suggesting that the development of herpes gestationis may depend on exposure to an antigen derived from the father. You can find out more about our use of cookies in About Cookies, including instructions on how to turn off cookies if you wish to do so. Advances in molecular analytical techniques now allow the identification of HLA alleles previously difficult to define by serological assays. A previous series has demonstrated an association of PG with human leukocyte antigen (HLA)-DR3 or HLA-DR4 haplotypes. These associations vary in different populations and ethnic groups. We performed HLA-DR typing on 30 patients with Bell’s palsy.