Herpes Zoster and Risk of Cancer in the Elderly U.S. Population. – PubMed

Among the subgroups stratified by sex, age and years of follow-up, there was also no increased risk of overall cancer. The incidence of HZ was 31/1,000 person-year (PY) in patients with hematologic malignancies and 12/1,000 PY in patients with solid tumors. METHODS: The Kaplan-Meier method was used to compute 1-year cancer-free survival rate. Kurland at the Department of Medical Statistics and Epidemiology, Mayo Clinic, Rochester, MN 55901. HZ complications are frequent and can present extra disease burden in cancer patients who develop HZ. For those with haematological cancer, however, the mortality was higher for herpes zoster patients than for controls. We identified HZ diagnosis using Medicare claims.

Compared with matched controls, these patients were more likely (p < 0.001) to have a history of myocardial infarction, asthma, congestive heart failure, chronic obstructive pulmonary disease, diabetes mellitus, and hypertension. The risk of subsequent cancer, particularly lung cancer, was significantly higher during the first 2 years after initial diagnosis of HZ. Patients with herpes zoster were not at increased risk of cancer (standardized incidence ratio 0.99, 95% confidence interval 0.93–1.06). The pooled relative risk for any cancer was 1.42 (95% confidence interval: 1.18, 1.71) overall and 1.83 (95% confidence interval: 1.17, 2.87) at one year after zoster. HZ complications are frequent and can present extra disease burden in cancer patients who develop HZ. No child developed visceral dissemination and there were no deaths. Patients with herpes zoster were not at increased risk of cancer (standardized incidence ratio 0.99, 95% confidence interval 0.93–1.06). We identified HZ diagnosis using Medicare claims. Previously, 17 of the 201 patients has been surgically treated for cancers (17/201 = 8.5%, predictable rate = 8.9%), eleven of these 17 patients had surgery for gastric cancer, or for colon cancer etc. HZ complications are frequent and can present extra disease burden in cancer patients who develop HZ. Above the age of 65 years we identified a significant increase of cancer emergence in the whole group and in females (hazard ratio = 2.65, 95% confidence interval = 1.43 to 4.90), but not in males. The response to treatment with acyclovir was generally favorable. Note: In calculating the moving wall, the current year is not counted. Logistic regression models were constructed to determine adjusted associations between cancer and HZ.

Among the failures, 2 patients had progressive VZV infection, 2 were hospitalized due to renal toxicity, and 1 developed a superinfection. The ulcers of HZ lesions were treated with chlorhexidine (Curasept) ointment to prevent secondary bacterial infection. Finally, we examined if the association depended on the included covariates through stratified analyses. Absorbed: Journals that are combined with another title. Patients with herpes zoster were not at increased risk of cancer (standardized incidence ratio 0.99, 95% confidence interval 0.93–1.06). Results: We identified 46 eligible studies, 10 of which considered all cancer types combined. The risk of a subsequent cancer diagnosis after herpes zoster infection: primary care database study.

Children with cancer had a higher risk of herpes zoster. The patient developed classical features of HZ during chemotherapy, 2 years after the initial chemotherapy for his bowel cancer. Results.Herpes zoster patients generally had greater use of inpatient, emergency room and outpatient services, and pain medications than matched controls (P < .05). All patients had a malignant disorder for which they had been given intensive chemo- or radiotherapy. A significant trend of decreasing prostate cancer risk with higher intake was found for legumes, nuts, finfish/shellfish and for alpha-tocopherol after adjustment for calcium intake. Herpes zoster patients (n = 2020, n = 1053, n = 286, n = 13 178, and n = 9089, respectively) were 1-to-1 matched to controls without HZ (with randomly selected index date) in the same baseline group. We performed analyses for all cancers combined, cancer subgroups (haematological cancers, immune-related cancers, smoking- and alcohol-related cancers and cancers at all other sites), and individual cancers (Boyle, 1997; Nasca, 2001; Boffetta and Hashibe, 2006). Sixteen patients developed VZV infection. The patient received valacyclovir, 1 g every 8 hours for 14 days, and his symptoms completely resolved after several weeks. Ozone was first used in medicine at the end of the 19th century to treat tuberculosis. In contrast, other methods available to treat high-risk skin cancers have cure rates of 50-90%. Regarding TNF inhibitors, there is an increased risk of infection (including serious infections) by bacterial pathogens, atypical fungi and opportunistic pathogens. Background: Herpes zoster is the clinical syndrome that occurs when latent varicella zoster virus is reactivated from dorsal root ganglia. Supported by a contract (AI-42527) with and grants (AI-05629 and CA-05828) from the U.S. In the rats given both drugs, bone marrow and intestinal membrane mucosa were greatly damaged at an early stage of the coadministration, and before death, the animals showed marked decreases in white blood cell and platelet counts, diarrhea with bloody flux, and severe anorexia, as was also manifested by the patients who subsequently died.