Herpes simplex encephalitis presenting with bilateral hippocampal lesions on magnetic resonance imaging, simultaneously complicated by

We report two pediatric cases of HSE complicated with Kluver Bucy syndrome and central diabetes insipidus. In 2 Patients antemortem diagnosis was possible and parenteral acyclovir could be administered in one case that recovered following treatment. All except one CSF sample obtained from the 2nd to the 8th day after onset of neurological symptoms yielded positive results. As soon as encephalitis in pregnancy is suspected, a combination of acyclovir and penicillin is recommended because the potential benefits far outweigh the risks. In 1993 the PCR was a double PCR. Polymerase chain reaction on cerebrospinal fluid (CSF) identified herpes simplex virus type 1 (HSV-1) as the causal agent. Bronchoalveolar carcinoma was widely disseminated in lungs and bones, and as three metastases in brain.

SPECT images showed decreased uptake not only in the temporal lobes but also in the frontal lobes. Analysis of a follow up CSF sample taken four months later showed no detectable HSV-2 DNA. brain biopsy) to confirm diagnosis of HSE and effective therapy may be carried out in time. The patient experienced visual hallucinations for about 1 week, and then experienced total loss of vision. We review other reported cases with focal retrograde amnesia and consider theoretical and neuroanatomical accounts for the present case. Their independent use by the patient was implemented through cues that were progressively reduced. The rate of adverse outcome is high and early antiviral treatment seems to be a strong predictor of clinical outcome.


He was transferred to our hospital with artificial ventilation on the same day. Follow-up analyses of patients who have undergone unilateral temporal lobectomy and have anterograde amnesia have shown hitherto undiscovered contralateral MTL damage (8). However, the CSF showed a positive polymerase chain reaction (PCR) for HSV type 1 DNA. The surgery had no complications. Table 1 shows characteristics of patients with and without viral encephalitis and Figure 1 depicts the frequency and spectrum of all causative viruses. UAB Station, Birmingham, AL 35294. The early diagnosis of HSE is essential because early introduction of antiviral therapy can significantly decrease mortality and morbidity associated with this disease.[1] Patients from Rajasthan and adjoining areas of Uttar Pradesh, Haryana, Punjab with provisional diagnosis of encephalitic illness, admitted in Neurology Department of SMS Medical College, Jaipur over a period of 2½ years (March 1997 to September 1999) were studied in detail.

The lone survivor was left with significant neurological deficits. Herein, we review the pathophysiology, differential diagnosis, and clinical and radiological features of herpes simplex virus-1 encephalitis in adults, including a discussion of the most common complications and their treatment. They can be either completely asymptomatic or present with signs of raised intracranial pressure, seizures (about 40% of cases), behavior changes, speech disorders, declining school performance, or hemiparesis. (1)H-MRS and diffusion-weighted imaging may both support the diagnosis of HSE in patients with AIDS and help in the follow-up of necrotizing inflammation. In 19/20 patients HSV DNA was present in the first CSF specimen. Curiously, till 1992 only occasional case reports were available.[2] In 1993, Satish Chandra et al[3] reported 9 cases of HSE and later in 1996 compiled data on 51 cases.[4] However, serological and clear epidemiological studies for viruses are not available in this part of the country, due to lack of virology research laboratories. Encephalitis caused by HSV-1 is rare, but it has the potential to cause significant brain damage or death.

Structured Silver gel will destroy the sexually transmitted diseases like gonorrhea, syphilis, HIV, herpes simplex and chlamydia. Herpes simplex encephalitis (HSE) is a serious viral infection with a high rate of mortality. Mr. Almost 2 months later, rhythmic, involuntary movements of the left hand developed. All children from this analysis group survived, only 8 demonstrated late complications: epileptic attacks (3), spastic tetraparesis (1), encephalopathy and mental disturbances (1). This is a notifiable disease in the UK (other than Scotland). Karl Bonhoeffer’s often forgotten but still relevant clinical insights on acute organic psychoses are then discussed in the light of recent research attempting to link manic states and infectious illness.

I am a woman (with herpes), and he has not. Herpetic infections have plagued humanity for thousands of years, but only recently have advances in antiviral medications and supportive treatments equipped physicians to combat the most severe manifestations of disease. An early diagnosis can greatly help to reduce mortality in both groups; however, since none of the presenting symptoms is pathognomonic for HSE, a clinical diagnosis is unreliable. She was treated with acyclovir and recovered completely to deliver a normal child per vaginam at term. At admission, she was stuporous, and a cerebrospinal fluid (CSF) analysis revealed pleocytosis (55/μl, monocytes). All patients diagnosed between 20 and 55 years of age with meningococcal (n = 451), pneumococcal (n = 553), or viral (n = 1,433) meningitis or with herpes simplex encephalitis (n = 115), who were alive 1 year after diagnosis, were identified.