Cytokine mRNA expression in lesions in cats with chronic gingivostomatitis. – PubMed

This early calicivirus infection may play some role in the sensitization of the oral tissues to an immune-mediated disease. Finally, if the inflammation is not widespread and is localized to a specific area, other diseases should be considered. Hennet P. A recent study showed clinical efficacy of the immunosuppressive agent cyclosporin. each) before any scaling was done. The most common dental problem in cats is periodontal disease. Not only has their use caused an ethical firestorm, it turns out they aren’t so great at treating disease, either: They also have the potential to form cancer.

The fauces of each cat were graded according to the clinical severity of the local lesions as follows: 0, no inflammation; 1, slight inflammation; 2, moderate inflammation; and 3, severe inflammation. One study by Hennet and others compared the use of interferon with other treatments. Cats infected with these viruses seem to develop an inappropriately severe reaction to plaque present with the mouth and on the teeth. Three weeks later, Bob returned to the VMTH for a second stem cell treatment. On day 42, the cat was premedicated and anesthesia was induced by using the same preanesthetic and anesthetic protcol as used during the earlier dental scaling and extraction. The presence of plaque bacteria may stimulate inflammation. The first one is the dog and obviously we would like at treatment for dogs as well, but even more importantly humans also get inflammation of their oral cavity,” said Verstraete.

Until the inflammation subsides, medical therapy will be necessary. Steroids should be utilized with care, as undesirable side effects can occur (such as diabetes). Additionally, the alveolar socket should be “smoothed down” with a high-speed drill bur before resuturing the gingiva. Whole-mouth extraction is vastly preferable to a life of oral pain and constant medication (and may be less expensive as well). Significant decrease in inflammation was noted and viral isolation was negative at 6, 10 and 14 weeks. Dry foods tend to encourage chewing and tend to be more abrasive but the relationship between food and dental disease is complex and the structure of the solid chunks of food is probably more important than whether the food is wet (tinned or sachet) or dry. A domestic cat does not actually need any teeth to eat well.

Additional funds came from the National Institutes of Health. Consequently, further characterization of the disease etiopathogenesis and host response is necessary to help facilitate the development of more effective medical treatments. It has been proposed that the disease is an exaggerated immune response to plaque and the tooth structure itself or the periodontal tissues as well as infectious antigens. There is testing available for the detection of bartonella and the antibiotic azithromycin has been effective in treating this bacteria. In the most advanced stage of the disease, the gum tissue will usually recede and the roots of the teeth will be exposed. No clinical recurrence has occurred following complete clinical remission (follow-up of 6–24 months). We are convinced that laser surgery is an appropriate worthwhile follow-up treatment for cats that do not respond to whole mouth extractions.

There is interest in thalidomide in veterinary medicine, primarily for treatment of metastatic cancers, but if that works well it will be tried for other things. In the clinical aspects of this project mandibular reconstruction technique using titanium plates and recombinant human bone morphogenetic protein-2 (rhBMP-2is used. Depending on the feline, all mentioned or site-specific pathology centers can be identified. A subset of cats remains unresponsive to treatments (~20-30%). This approach sounds daunting to most cat parents, but if it is done by an experienced veterinary dentist, with proper pain control protocols, most cats tolerate the treatment well and recover quickly. Ulcerative Stomatitis: This condition occurs when a significant amount of gum tissue is lost in a cat’s mouth, and is frequently accompanied by inflammation of the oral tissues. If i can keep him comfortable, that’s all I ask.

Create an account for free to read full articles on However, none of these treatments are ideal, predictable and without possible complications. In 60 percent of cases, extraction of these teeth results in complete recovery with no need for further medication. Full or near full tooth extractions which only has 60-80% cure rate Short term immunosuppression with steroids, which can lead to adverse effects such as further infections, diabetes and Cushing’s Disease Antibiotic treatment, which may reduce secondary infection, but does not result in a cure, or Interferon Gamma treatment, which, like steroid use, has not been shown to have long term success in cats. The differential diagnosis for severe oral inflammation in a feline patient includes: gingivostomatitis, periodontal disease, resorptive lesions (RL’s), viral disease (FELV, FIV, herpes, calicivirus), bartonella, eosinophlic granuloma, and neoplasia. The most common sign of pain in cats, however, is no sign at all.